In this study, published in the Proceedings of the National Academy of Sciences, we found that over 500 genes were affected by lifestyle changes. In fact, certain disease preventing genes were up-regulated, or turned on, and certain disease promoting genes, including oncogenes involved in cancer, were down-regulated, or turned off. The results of this study suggest that comprehensive lifestyle changes may cause changes in gene expression that could be beneficial to the general population as well as to those with prostate cancer.

Changes in prostate gene expression in men undergoing an intensive nutrition and lifestyle intervention.

Proceedings of the National Academy of Sciences (PNAS):
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